Top-selling insulin associated with increased cancer risk

A presentation at the San Antonio Breast Cancer Symposium revealed an increased risk of cancer in association with insulin glargine, the world’s top-selling long-acting insulin analog which is marketed under the brand name Lantus®. In contrast, use of the antidiabetic drug metformin, available as a low-cost generic, was associated with an impressive reduction in cancer risk.

Hakan Olsson and colleagues from Sweden’s Lund University analyzed data from 2,724 cancer patients up to ten years prior to diagnosis and 20,542 subjects with no history of the disease. They found that having diabetes within four years prior to being diagnosed with breast cancer was associated with a 37 percent greater risk of this type of cancer compared to nondiabetics. Obesity after the age of 60 was associated with a 55 percent greater breast cancer risk, and abnormally low blood lipids with a 25 percent greater risk in comparison with those who did not have these conditions.

When prescription drug use was examined, insulin glargine, a biosynthetic long-acting insulin analog, was associated with a whopping 2.9-times increased risk of cancer, whereas metformin was associated with a reduced risk of 8 percent. Although not all long-term studies of Lantus® suggest increased cancer risk, there remains concern that long-acting insulin analogs like Lantus® may have the potential to increase cancer risk.

Biosynthetic insulin analogs like Lantus® (insulin glargine) are not exactly the same as human insulin. Enhanced reactivity with the IGF-1 receptor are characteristics of these drugs. Stimulation of the IGF-1 (insulin-like growth factor-1) receptor has been shown in several studies to enhance tumor cell growth and proliferation. For example, insulin B10Asp, the first of the analogs to be developed, was based on a single amino acid substitution in comparison with human insulin. This was sufficient to produce a ten-fold increase in cell division (mitogenicity) compared with human insulin.

Modification of specific regions of the B-chain molecule associated with insulin (specifically, the B26–B30 regions of the B-chain) increase IGF-1 receptor binding, as does modification of the B10 residue and extension of the B-chain by addition of arginine residues. These modifications can produce a nearly 90-fold increase in binding to the IGF-1 receptor. Lantus® (insulin glargine) contains arginine residues at positions B31 and B32, together with a glycine substitution at A21.

While the use of insulin is a necessity for some type 2 diabetics, Life Extension® has long recommended that those who have diabetes or are at risk of the disease make every effort to control their blood glucose levels with a combination of consuming fewer and healthier calories, engaging in regular exercise, and supplementing with beneficial nutrients that may be insufficiently supplied by the diet. Soluble fiber, green bean coffee extract, magnesium, Irvingia gabonensis seed extract, L-carnitine, alpha-lipoic acid, and green tea are just a few examples of nutrients that can help support healthy glucose metabolism. Life Extension has long advocated an aggressive, integrative strategy to reduce ingested calorie intake and support healthy glucose metabolism. For more information, please contact a Life Extension Health Advisor at 1-800-226-2370.

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Reduced childhood vitamin D levels predict diabetes

Friday, December 9, 2011. In an article appearing in the January, 2012 issue of the Journal of Clinical Endocrinology & Metabolism, Micah Olson, MD, of the University of Texas Southwestern Medical Center in Dallas and her associates report that children suffering from obesity and insulin resistance (which are both associated with diabetes) are more likely to have reduced serum levels of vitamin D in comparison with non-overweight children.

The current study evaluated serum 25-hydroxyvitamin D levels, fasting glucose and insulin levels, insulin resistance and other factors in 411 obese and 87 non-overweight children between the ages of six and sixteen residing in North Texas. Dietary information collected from the participants included daily intake of milk, soda, juice, fruit and vegetables, and whether or not the subject regularly ate breakfast.

While 68 percent of non-overweight participants had insufficient vitamin D levels of less than 75 nanomoles per liter (nmol/L) and 22 percent had deficient levels lower than 50, among obese children, the incidence of insufficiency and deficiency rose to 92 and 50 percent. Low vitamin D levels were associated with drinking more sodas and juice as well as with skipping breakfast. Among obese children, a significant relationship was observed between increased insulin resistance with lower vitamin D levels.

In their discussion of the findings, the authors note that “the difference in mean 25-hydroxyvitamin D levels between obese and non-overweight subjects was 18.5 nmol/L. Obese children would need to consume an extra 600 to 1200 IU (the equivalent of six to twelve 8-ounce cups of milk) of cholecalciferol daily to make up the difference in mean 25-hydroxyvitamin D levels seen in our study. Thus, poor dietary habits alone cannot explain the low 25-hydroxyvitamin D levels seen in obese children.”

“Our study found that obese children with lower vitamin D levels had higher degrees of insulin resistance,” stated Dr Olson, who is affiliated with Southwestern Medical Center’s Department of Pediatrics. “Although our study cannot prove causation, it does suggest that low vitamin D levels may play a role in the development of type 2 diabetes.”

“Poor dietary habits such as skipping breakfast and increased soda and juice intake were associated with the lower vitamin D levels seen in obese children,” she added. “Future studies are needed to determine the clinical significance of lower vitamin D levels in obese children, the amount and duration of treatment necessary to replenish vitamin D levels in these children and whether treatment with vitamin D can improve primary clinical endpoints such as insulin resistance.”

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Getting the most out of your vegetables

Nicola Menke, dpa
Deutsche Presse-Agentur (dpa)

11-25-11

Berlin (dpa) – Vegetables are healthy foods bursting with vitamins, minerals and carbohydrates, and they should be on everyone’s plate every day.

Each type of vegetable offers its own nutritive substances and people can cover their nutritional needs by eating a variety of them, said Silke Restemeyer of the German nutrition organization. Thus, an A (as in aubergine) to Z (as in zucchini) approach is best for getting the most out of the wide variety of vegetables.

Nutritionists warn, however, that vegetables can lose a lot of their nutritional value when they are cooked. They agree that steaming is the best way to prepare them, but they also note that of the recommended five portions of vegetables and fruits a person should eat, at least one should be raw or in a salad.

“Basically, uncooked vegetables are the richest in vital substances,” said Restemeyer.

But of course, people can eat whatever tastes best to them. For some that means lightly steamed, while others would rather have them stewed, braised, grilled or roasted. And while one person likes them well-seasoned, another prefers them in a cream sauce.

Heat is what causes vegetables to lose their nutrients, but there is a big difference between the extent to which they are lost depending on the cooking method used.

“Among the most nutrient-preserving ways to cook vegetables are steaming, cooking them in their own juices or with just a little bit of water, wine or broth,” said Margret Morlo of an association in Germany devoted to nutrition and diet.

The reason is not solely that many vitamins, including C and B1, as well as all minerals are water-soluble and because these methods use little water the vitamins and minerals remain in the food. Usually, they are steamed at a low temperature and only until the vegetables are al dente. Steaming them at a high heat for too long destroys their nutritional content.

Vegetables such as carrots retain a similar amount of their nutrients when they are cooked in water. This can be done in a steamer or in a regular pot with a vegetable sieve. Another way to preserve nutrients is to cook the vegetables in hot oil in a skillet or wok until the vegetables are al dente.

Yet another alternative is to marinate the vegetables and then grill them or roast them in the oven for 30 minutes, said Carsten Voigt of an association for cooks in Germany. “These methods are equally as protective of the nutrients and you obtain a delicious roasted flavour,” he said.

The cooking methods that cause the greatest loss of nutrients are slow cooking in a lot of liquid at high temperatures – 75 to 95 degrees Celsius – and classic simmering. Shorter cooking times mean fewer vitamins are lost compared with longer cooking times, said Voigt. In addition, cooking experts recommend using as little liquid as possible because the more liquid in the pot, the greater amount of minerals lost.

For the same reason vegetables shouldn’t be cut in small pieces or peeled before being prepared. “Removing the peel is a shame because it contains the highest vitamin content and the most flavour,” said Voigt.

There are a few other tricks that can minimize the loss of nutrients. “The lid should be tightly closed and seldom opened when cooking vegetables so that as little of the nutrients as possible can evaporate,” said Morlo. The water remaining in the pot, along with any nutrients that it has absorbed, can be used in a sauce or broth poured over the vegetables.

Cooks also should be aware that not every way to cook vegetables is appropriate for every type of vegetable. Firm vegetables such as beetroot are best suited for cooking, while soft vegetables such as broccoli should be steamed. The question of whether to cook a vegetable or eat it raw also depends on the type.

Some vegetables such as cabbage become more digestible when cooked. Raw green beans, for example, must be cooked for 10 minutes at 100 degrees Celsius to neutralise a protein that can be toxic if consumed by humans. In addition there are nutrients in plants that the body can make better use of when cooked. These include secondary nutrients such as lycopene in tomatoes.

Ripeness is another factor in ensuring that vegetables have as many nutrients as possible. They are at their peak in terms of nutrition when they are ripe and fresh. Finally, vegetables should be stored in a cool, dry and dark place.

Copyright 2011 dpa Deutsche Presse-Agentur GmbH

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Drug reverses aging-associated changes in brain cells: study

Xinhua News Agency – CEIS

12-08-11

Drug reverses aging-associated changes in brain cells: study

WASHINGTON, Dec. 7 (Xinhua) — Drugs that affect the levels of an important brain protein involved in learning and memory reverse cellular changes in the brain seen during aging, according to an animal study published Wednesday in the Journal of Neuroscience. The findings could one day aid in the development of new drugs that enhance cognitive function in older adults.

Aging-related memory loss is associated with the gradual deterioration of the structure and function of synapses (the connections between brain cells) in brain regions critical to learning and memory, such as the hippocampus.

Recent studies suggested that histone acetylation, a chemical process that controls whether genes are turned on, affects this process. Specifically, it affects brain cells’ ability to alter the strength and structure of their connections for information storage, a process known as synaptic plasticity, which is a cellular signature of memory.

In the current study, Cui-Wei Xie, of the University of California, Los Angeles, and colleagues found that compared with younger rats, hippocampi from older rats have less brain-derived neurotrophic factor (BDNF) — a protein that promotes synaptic plasticity — and less histone acetylation of the Bdnf gene. By treating the hippocampal tissue from older animals with a drug that increased histone acetylation, they were able to restore BDNF production and synaptic plasticity to levels found in younger animals.

“These findings shed light on why synapses become less efficient and more vulnerable to impairment during aging,” said Xie, who led the study. “Such knowledge could help develop new drugs for cognitive aging and aging-related neurodegenerative diseases, such as Alzheimer’s disease,” she added.

(c) 2011 Xinhua News Agency – CEIS. Provided by ProQuest LLC. All rights Reserved.

Copyright Xinhua News Agency – CEIS 2011

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Cenegenics Carolinas Offers Top Tips for a Healthier Holiday Season

PRNewswire

12-07-11

CHARLESTON, S.C., Dec. 6, 2011 /PRNewswire/ — Age Management Physicians from Cenegenics Carolinas, a preventive health and age management medical facility, today released their top tips for staying healthy over the 2011 holiday season.

Exercise

Staying active during the holiday season can prove to be a tough challenge.

Tip: Try to exercise for 10 minutes three times a day. A great 10-minute workout can include walking up and down stairs or jumping rope.

Drink Plenty of Water

The number one cause of daytime fatigue is dehydration.

Tip: Try to drink eight ounces of water a day and consume foods and beverages high in water.

Monitor Alcohol Consumption

Alcoholic drinks are loaded with calories and little or no nutritional value.

Tip: Moderation and smart beverage choices. Avoid beverages like eggnog and rum and coke. Instead, opt for a light beer or vodka mixed with sparkling water.

Get Enough Sleep

With the stress of the holidays sleeping can be a challenge.

Try these tips for a good night’s rest:

– Try foods that help promote sleep.

– Limit alcohol consumption.

– Set the room temperature between 68 and 72 degrees Fahrenheit.

– Avoid foods and drinks that contain caffeine after 2 p.m.

Eat a Healthy Breakfast

Choose a breakfast that includes protein and healthy fats and don’t skip breakfast as this can lead to overeating.

Avoid the Afternoon Lull

To beat the mid-afternoon crash, start the day with the proper nourishment and avoid heavy lunches. If in need of an energy boost, try taking a brisk walk.

Conquer Temptation

Eat a small meal before going out and plan for temptation. Studies show that when people plan out exactly what they’ll do when temptation arises, they are two to three times more likely to achieve their dietary goals.

Dealing with Holiday Stress

As our cortisol (stress hormone) rises, it compromises the production of other important hormones such as DHEA, pregnenolone and progesterone. Try to increase these hormone supplements during stressful times.

Prevent Colds

Nothing’s worse than getting a cold during the “most wonderful time of the year.” Take precautions by eating plenty of immune-boosting foods, take a multi-vitamin and get plenty of sunshine to maintain optimal health.

Spice up the Holidays

Studies show that adding certain spices to food can help boost metabolism including: cayenne pepper, cinnamon, turmeric, paprika, black pepper and other hot peppers.

Cenegenics Carolinas

CONTACT: CONTACT: Erin Barrett, +1-843-916-2000,ebarrett@thebrandonagency.com

Web site: http://www.cenegenicscarolinas.com/

Copyright PRNewswire 2011

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AMD-like lesions delayed in mice fed lower glycemic index diet

NewsRx.com

11-25-11

Feeding older mice a lower glycemic index (GI) diet consisting of slowly-digested carbohydrates delays the onset of age-related, sight-threatening retinal lesions, according to a new study from the Laboratory for Nutrition and Vision Research at the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts University.

The researchers studied middle-aged and older mice that consumed either a higher or lower GI diet. Mice fed the lower GI diet developed fewer and less-severe age-related lesions in the retina than the mice fed the higher GI diet. The lesions included basal laminar deposits, which typically develop after age 60 in the human retina and are the earliest warning sign of Age-Related Macular Degeneration (AMD).

“To our knowledge, we have established the first mature, mammalian model indicating a delay in the development of AMD-like lesions as the result of a lower GI diet,” says Allen Taylor, PhD, director of the Laboratory for Nutrition and Vision Research at the USDA HNRCA. “The only difference between the two groups of mice we studied is the GI of their meals, which suggests that diet alone is enough to accelerate or delay the formation of lesions. These results, coupled with similar observations made by our laboratory in earlier human epidemiologic studies imply that lower GI diets hold potential as an early intervention for preventing onset and progress of AMD.”

The dietary glycemic index (DGI) measures the rate at which glucose is delivered to the bloodstream after consuming carbohydrates. Higher GI foods including white bread and white potatoes trigger a rapid delivery of glucose that pushes the body to work overtime to absorb, whereas lower GI foods, like whole grain bread and fruits and vegetables, initiate a slower release of glucose that is more easily processed by cells (see also Age-Related Macular Degeneration).

Compared to the mice on the lower GI diet, mice on the higher GI diet demonstrated elevated accumulations of debris known as advanced glycation end products (AGEs) in the whole retina, particularly in the cells of the RPE. The RPE plays a crucial role in maintaining vision and its dysfunction results in the gradual central vision loss that is the hallmark of AMD. AGE accumulation has also been linked to tissue damage in other age-related diseases such as Type 2 diabetes and cardiovascular disease.

“We presume the elevated accumulation of AGEs we saw in the retina of the higher GI group is associated with toxicity. The AGEs result from the modification of proteins by excess glucose and this compounds the normal protein damage that happens as we age,” says Karen Weikel, first author and a PhD candidate at the Friedman School of Nutrition Science and Policy at Tufts. “While previous research has linked higher GI diets to AGE accumulation in the blood, ours appears to be the first to show diet-related AGE presence in tissue, such as the retina, which becomes the site of the eye disease.”

The research, published online in October in the journal Aging Cell traces the drop-off in AGE accumulation in the lower GI diet to the ubiquitin-protease system pathway and the lysosome/autophagy pathway. “In cell models we saw that both the ubiquitin pathways and lysosome pathways processed proteins more efficiently and kept cells healthier when glucose levels were lower,” says Taylor, who is also a professor at the Friedman School and Tufts University School of Medicine (TUSM). “Both pathways are well-known for their ability to remove damage from cells, but this had not been previously systematically explored for removal of AGEs.”

The Centers for Disease Control reports AMD is the chief cause of irreparable vision loss in Americans over age 65 and that 1.8 million people in the U.S. are living with the disease, a number that is expected to approach 3 million by 2020.

“Although our laboratory has shown in epidemiological studies and now in a live laboratory model that lower GI diets may prevent or delay the progression of AMD, future studies are needed. Trials involving more animals and human clinical trials could more carefully describe the protein-editing machinery that appeared to determine the development and severity of the lesions we saw,” Taylor says. “With such information, we may begin to develop cost-effective dietary interventions as well as a new generation of drugs that mimic the presumed effects of the lower GI diet to prolong vision.”

Keywords: Peptides, Agriculture, Amino Acids, Diet and Nutrition, Intracellular Space, Cytoplasmic Vesicles, Cytoplasmic Structures, Tufts University Health Sciences Campus.

This article was prepared by Patient Care Law Weekly editors from staff and other reports. Copyright 2011, Patient Care Law Weekly via NewsRx.com.

To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .

2007 NewsRx.com. All Rights Reserved.Copyright 2011, Patient Care Law Weekly via NewsRx.com

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Take steps to counter poor balance and risk of falling

washingtonpost.com

11-25-11

Having poor balance is a health risk. Falls are the leading cause of hospital admissions for people older than 65, with one in three experiencing a fall each year. Twenty to 30 percent of those incidents result in such injuries as lacerations, hip fractures and head traumas, as well as hospital bills averaging nearly $18,000 per patient, according to the Centers for Disease Control and Prevention.

“It’s important to understand, however, that this risk of falling isn’t caused simply by aging, but rather [is] an effect of illnesses and impairments common in older adults,” says Mary Tinetti, a professor of internal medicine at the Yale School of Medicine. “In general, the more chronic health conditions you have, the more likely you are to suffer a fall.”

Here’s why.

A person’s ability to balance is influenced by many factors, including vision, gait, inner-ear functioning, blood pressure, muscle strength and posture. The brain integrates information it receives and uses it to tell your body how to move safely. It can compensate if one or two of those factors are compromised, “but it’s more difficult to overcome multiple problems to the system,” Tinetti says.

For example, diabetes can worsen vision and desensitize nerves in the feet. Depression is known to increase the risk of falling, although Tinetti says researchers don’t know exactly how this happens. Hypertension drugs can cause dizziness or a drop in blood pressure upon standing. “In fact, a lot of medications affect balance; many drugs that target the brain increase your risk of falling,” she says, adding that sleep aids are some of the worst offenders.

If you’ve had unexplained falls or feel unsteady on your feet, or if someone notices that you seem wobbly, see your doctor to check on any underlying causes. You might be referred to a physical therapist, who can evaluate your balance and suggest strengthening exercises.

Taking a quick at-home balance test can also help define your risk. Get up from a chair, walk 10 feet, turn around, walk back and sit down. Any sign of unsteadiness should be of concern, Tinetti says.

Other strategies to bolster balance include yoga, tai chi (the Chinese martial art of slow, rhythmic movements), and low-impact dancing. It’s important to strengthen your arms, too, since you use them to steady yourself. It might be worth scheduling a few sessions with a certified personal trainer. At home, remove throw rugs and fix slippery surfaces to avoid missteps and falls.

Copyright 2011. Consumers Union of United States Inc.

For more news, or to subscribe to the newspaper, please visit http://www.washingtonpost.com

Copyright washingtonpost.com

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High Blood Sugar Levels in Older Women Linked to Colorectal Cancer

PRNewswire-USNewswire

11-30-11

BRONX, N.Y., Nov. 29, 2011 /PRNewswire-USNewswire/ — Elevated blood sugar levels are associated with an increased risk of colorectal cancer, according to a study led by researchers at Albert Einstein College of Medicine of Yeshiva University. The findings, observed in nearly 5,000 postmenopausal women, appear in the November 29 online edition of the British Journal of Cancer.

According to the American Cancer Society, colorectal cancer is the third most commonly diagnosed cancer and the third leading cause of cancer death in both men and women in the U.S.

Statistics compiled by the U.S. Centers for Disease Control and Prevention for 2007 (the most recent year for which figures are available) show that 142,672 Americans were diagnosed with colorectal cancer, including 69,917 women; the 53,219 deaths from colorectal cancer that year were divided almost equally between men and women.

The Einstein study involved women who were enrolled in the National Institutes of Health’s landmark Women’s Health Initiative study. For these women, fasting blood sugar and insulin levels had been measured at baseline (i.e., the start of the study) and then several more times over the next 12 years.

By the end of the 12-year period, 81 of the women had developed colorectal cancer. The researchers found that elevated baseline glucose levels were associated with increased colorectal cancer risk–and that women in the highest third of baseline glucose levels were nearly twice as likely to have developed colorectal cancer as women in the lowest third of blood glucose levels. Results were similar when the scientists looked at repeated glucose measurements over time. No association was found between insulin levels and risk for colorectal cancer.

Obesity–usually accompanied by elevated blood levels of insulin and glucose–is a known risk factor for colorectal cancer. Researchers have long suspected that obesity’s influence on colorectal cancer risk stems from the elevated insulin levels it causes. But the Einstein study suggests that obesity’s impact on this cancer may be due to elevated glucose levels, or to some factor associated with elevated glucose levels.

“The next challenge is to find the mechanism by which chronically elevated blood glucose levels may lead to colorectal cancer,” said Geoffrey Kabat, Ph.D., a senior epidemiologist at Einstein and lead author of the paper. “It’s possible that elevated glucose levels are linked to increased blood levels of growth factors and inflammatory factors that spur the growth of intestinal polyps, some of which later develop into cancer.”

The paper is titled “A Longitudinal Study of Serum Insulin and Glucose Levels in Relation to Colorectal Cancer Risk among Postmenopausal Women.” Other Einstein authors are Mimi Kim, Sc.D., and Howard Strickler M.D., both professors in the department of epidemiology and population health, and senior author Thomas E. Rohan, M.D., Ph.D., professor and chair of epidemiology and population health.

About Albert Einstein College of Medicine of Yeshiva University

Albert Einstein College of Medicine of Yeshiva University is one of the nation’s premier centers for research, medical education and clinical investigation. During the 2011-2012 academic year, Einstein is home to 724 M.D. students, 248 Ph.D. students, 117 students in the combined M.D./Ph.D. program, and 368 postdoctoral research fellows. The College of Medicine has 2,522 full time faculty members located on the main campus and at its clinical affiliates. In 2011, Einstein received nearly $170 million in awards from the NIH. This includes the funding of major research centers at Einstein in diabetes, cancer, liver disease, and AIDS. Other areas where the College of Medicine is concentrating its efforts include developmental brain research, neuroscience, cardiac disease, and initiatives to reduce and eliminate ethnic and racial health disparities. Its partnership with Montefiore Medical Center, the University Hospital and academic medical center for Einstein, advances clinical and translational research to accelerate the pace at which new discoveries become the treatments and therapies that benefit patients. Through its extensive affiliation network involving Montefiore and four other hospital systems in the Bronx, Manhattan and Long Island, Einstein runs one of the largest post-graduate medical training programs in the United States, offering 155 residency programs to 2,244 physicians in training. For more information, please visit www.einstein.yu.edu and follow us on Twitter @EinsteinMed.

Albert Einstein College of Medicine

CONTACT: CONTACT: Kimberly Newman, +1-718-430-3101,Sciencenews@einstein.yu.edu

Web site: http://www.aecom.yu.edu/

Copyright PRNewswire-USNewswire 2011

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Mid-morning snack may sabotage weight loss

United Press International

11-30-11

Women dieters who snack between breakfast and lunch do not lose more weight compared with those who abstain from a mid-morning snack, U.S. researchers say.

Study leader Dr. Anne McTiernan of the Fred Hutchinson Cancer Center said the study involved 123 overweight-to-obese postmenopausal Seattle-area women ages 50-75.

The women were randomly assigned to either a diet-alone intervention with a goal: 1,200 to 2,000 calories a day, depending on starting weight, and fewer than 30 percent of daily calories from fat, or diet plus exercise with the same calorie and fat restrictions plus 45 minutes of moderate-to-vigorous exercise per day, five days a week. The women, who received nutrition counseling, were not given any specific instructions or recommendations about snacking. For the purposes of the study, a snack was defined as any food or drink consumed between main meals.

The findings, scheduled to be published in the December issue of the Journal of the American Dietetic Association, found mid-morning snackers lost an average of 7 percent of their total body weight while those who ate a healthy breakfast but did not snack before lunch lost more than 11 percent of their body weight.

“We think this finding may not relate necessarily to the time of day one snacks, but rather to the short interval between breakfast and lunch. Mid-morning snacking therefore might be a reflection of recreational or mindless eating habits rather than eating to satisfy true hunger,” McTiernan said in a statement.

Copyright United Press International 2011

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Fitness tips from top trainers

Chicago Tribune

11-25-11

North America’s top fitness professionals don’t necessarily train celebrities and professional athletes or badger overweight reality-TV contestants into shape.

Instead, they work with recreational runners who want to get faster, they inspire virtual clients online and they make fitness classes innovative and challenging.

These three fitness phenoms were all recently honored by their industry as the cream of the crop. They’ve shared a few of their most effective secrets to help you get motivated or refresh your workouts:

JASON KARP

Karp aspires to be “the Jillian Michaels of running,” if only because the broad exposure would help him reach runners of all abilities. Karp is a big fan of the objectivity and the science of the sport: In races, there’s a start line, a finish line and one winner. “I’ve always been interested in what makes someone faster than another person and how they got there,” said Karp, the 2011 IDEA Health and Fitness Industry Personal Trainer of the Year who works in San Diego. “People think running is so simple,” he added. “But a lot of people giving running advice have no idea what they’re talking about.”

Karp’s top tips:

Polarize your training. Recovery is the secret behind improvement; it can mean taking a day off or working at a lower intensity. With runners, Karp stresses going all out on hard days and relaxing on easy days. “Most people — especially gymgoers — make their workouts all in the middle,” he said. “It’s the same thing every day. With really hard days, you force adaptations that cause stress; then you recover by working easy.”

Ease into it. If you’ve been sedentary for 40 years, don’t sign up to run a marathon in six months. The other thing that drives Karp crazy? Going out too fast during the first mile of a race. Run a pace you can maintain the entire time, Karp said.

Make interval workouts harder. Many runners try to do this by running the intervals at a faster pace. Instead, decrease your recovery time between intervals, make the interval period longer or increase repetitions. “Raise the peak of the pyramid from the bottom,” Karp said. “You’ll be producing more mitochondria to do the aerobic work. When you can do more and more work at the same intensity, you’ll be getting faster.”

——

NICOLE NICHOLS

The 29-year-old Nichols, recognized as “America’s Top Personal Trainer to Watch” by the American Council on Exercise and Life Fitness, has been on both sides of the fitness fence. As a teenager, she developed unhealthy exercise and eating habits — even though she thought she was working out correctly. In college, she struggled, bouncing from intense workouts to bagging exercise and gaining 40 pounds.

“I was miserable,” Nichols, of the Cincinnati area, recalled. But as she learned more about personal training, she discovered “how to practice moderation, not just in food, but exercise,” she said. “Fitness isn’t about achieving a certain physique or going to extremes. It’s about exercising in ways that are fun, fit into life easily and don’t cause you to give up other things.”

Nichols’ top tips:

Morning exercise works. Get up 15 minutes earlier to squeeze in a short workout. “It’s one of the best ways to make sure nothing gets in the way,” she said. As a non-morning person, Nichols forces herself up and out of bed two to three days a week for a run, knowing that she’ll feel far worse if she blows it off. Make it easier: Sleep in your workout clothes.

Don’t work out on an empty stomach. “It’s not going to result in greater fat burning,” said Nichols. “What’s most important for weight loss is burning total calories. If you are not eating in the morning or for a long time before you exercise, you won’t be able to work out at an optimal level, and that’s more detrimental,” she said. About 30 minutes before a workout, try a small snack of 100 to 200 calories, which could include fruit juice, half a bagel or an energy bar with 3 to 5 grams of protein and at least 15 grams of carbs. If you have an hour or two, try whole grain crackers with nut butter, hard-boiled eggs, nuts or oatmeal.

Walk — even if you can run. Walking is an important part of an exercise plan, even for fit people. “Every bit of physical activity is beneficial,” Nichols said. “It’s wrong for people to think they have to work out intensely to benefit. In fact if your workouts are always intense, you might be setting yourself up for failure. If you’re having trouble getting started, just do 10 minutes a day to start building a habit. “That’s over an hour a week. Then work up to three 10-minute chunks in a day,” she said.

——

LEIGH CREWS

Crews, IDEA’s Fitness Instructor of the Year, has what her husband jokingly calls a “certification addiction.” Over the last three decades, the 55-year-old dynamo from Alabama has taught everything from step aerobics and glide classes to her current favorites: TRX Suspension Training and Batuka, a new pre-choreographed dance fitness program.

The challenge for fitness instructors is that “we need to have the depth of a personal trainer and, at the same time, we have to distill our instructions down to their very essence to serve a group situation,” she said. Her passion now is training other fitness professionals, which she does through her fitness education company, Dynalife.

Crews’ top tips:

Find what you like. Then do it. “Make that the cornerstone of your workout, because if you don’t like it, you won’t stick to it,” she said. Round out that activity with something complementary. If you like to run, for example, then run. But balance it with some yoga or strength training.

Eat food as close to its natural state as possible. Eating the orange is always better for you than drinking the orange juice. Also stay away from refined or processed foods and limit the amount of high-fat protein such as meat that you eat each week. “Going all veggie is always an option,” Crews said.

Don’t hang out in the back row. Group fitness classes can improve your odds for success, as the class tends to become one big family, said Crews. But if you’re uncertain about your abilities, “let the instructor know you are a newbie, and position yourself where you can see yourself in the mirror and see the instructor,” said Crews. “It will be much easier to follow, learn and look like you already know what you’re doing in there.”

——

(c)2011 the Chicago Tribune

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Copyright Chicago Tribune 2011

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